Prelude Therapeutics and AbCellera have entered a partnership to develop first-in-class cancer treatments using antibody drug conjugates (ADCs). Combining Prelude’s small molecule prowess with AbCellera’s antibody discovery, they aim to advance new ADCs targeting oncology pathways. They will co-develop and commercialize these therapies, with AbCellera overseeing manufacturing and Prelude handling clinical trials and sales, and AbCellera possibly co-promoting in the U.S. The full announcement includes multimedia content available online.
Prelude Therapeutics Incorporated (“Prelude”) (Nasdaq: PRLD) and AbCellera (Nasdaq: ABCL) today announced a multi-year, multi-program partnership to discover, develop, and commercialize potentially first-in-class treatments for patients with cancer. The collaboration combines Prelude’s expertise in targeted protein degradation, medicinal chemistry, and clinical development with AbCellera’s antibody discovery and development engine to generate novel precision antibody drug conjugates (ADCs). The first program, which benefits from a lead panel of antibodies previously discovered by AbCellera, is focused on ADCs to broaden the reach of Prelude’s small molecule SMARCA2 selective degraders to address a larger patient population.
“By leveraging our combined capabilities and expertise in rapidly discovering and advancing novel candidates into the clinic, this collaboration provides an opportunity to build a pipeline of first-in-class ADCs targeting clinically validated pathways in oncology,” said Kris Vaddi, Ph.D., Founder and CEO of Prelude.
“Through this strategic partnership we are combining deep expertise in antibody and small molecule development to create precision ADC therapies for patients in need,” said Carl Hansen, Ph.D., Founder and CEO of AbCellera.
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Under the terms of the agreement, Prelude and AbCellera will jointly discover, develop, and commercialize products emerging from the collaboration. AbCellera will lead manufacturing activities and Prelude will lead clinical development and global commercialization, subject to AbCellera’s option to co-promote any resulting commercial products in the United States.
Source: Biospace
