Tonix Pharmaceuticals, Inc. Holding Corp. (Nasdaq: TNXP) (Tonix or the Company), a clinical-stage biopharmaceutical company, today announced an agreement whereby Tonix will acquire the migraine and pain treatment technologies of Trigemina, Inc., and will assume the license for some of the technologies from Stanford University. The lead asset, TNX-1900 (formerly TI-001, oxytocin solution for intranasal delivery), is a proprietary, patented enhanced formulation of nasal oxytocin, with demonstrated activity in several non-clinical studies in pain including migraine prophylaxis and neuropsychiatric models and with safety data from non-U.S. studies.
“Tonix is excited to develop intranasal oxytocin as a non-addictive treatment for migraine and craniofacial pain,” said Seth Lederman, M.D., President and Chief Executive Officer. “The preclinical data that we have seen to date are promising and show that oxytocin, a natural hormone, is capable of blocking the release of the neurotransmitter calcitonin gene-related peptide (CGRP) in the brain coverings and trigeminal ganglia, thus potentially preventing a key step in the causation of migraine. It has been shown that intra-nasally delivered oxytocin selectively reaches the trigeminal ganglia with low systemic absorption. Overall, we believe that TNX-1900 has the potential to be a safe, natural, non-addicting, non-constipating and easy to administer alternative to opioids to treat migraine and craniofacial pain.”
“We are excited that Tonix will continue to advance the progress Trigemina has made with these assets and look forward to potentially facilitating their development,” said Shashidar H. Kori, M.D., Chief Medical Officer, Trigemina Inc. “This agreement further validates our previous development work and its continued potential.”
Source: BioSpace
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